布林佐胺 T0142

Product Introduction
Bioactivity


英文名: Brinzolamide

描述: Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。

体外活性: 0.6 mg Brinzolamide眼悬液可以以剂量依赖的方式降低激光治疗青光眼手术后食蟹猴的眼内压.< 1 mg Brinzolamide眼悬液可以以剂量依赖的方式降低荷兰束带兔眼内压.1 mg/kg,10 mg/kg和30 mg/kg剂量 Brinzolamide可以分别使雄性CD-1小鼠的巴比妥睡眠时间延长57%,15%和35%.< 3%的Brinzolamide可以使原发性开角型青光眼病人或高眼压病人的平均眼内压下降百分比和平均眼内压下降值比安慰剂组明显增多.对于安静状态下的荷兰束带兔,2%的Brinzolamide可以增加其视神经乳头血流量并降低其眼内压.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 71 mg/mL (185.1 mM)


关键字: IOP | Brinzolamide | glaucoma | intraocular pressure | Carbonate dehydratase | inhibit | Inhibitor | atrial fluid | AL4862 | Carbonic Anhydrase | AL 4862 | carbonic anhydrase II

相关产品: hCA/VEGFR-2-IN-1 | Fluorometholone Acetate | hCAI/II-IN-6 | Histone acetyltransferase p300 Inhibitor 4c | (Iso)-Samixogrel | Trichlormethiazide | CA inhibitor 2 | Sultiame | hCAIX-IN-15 | 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Hypertension Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Human Metabolite Library | Inhibitor Library | EMA Approved Drug Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library

布林佐胺 T0142信息由TargetMol中国为您提供，如您想了解更多关于布林佐胺 T0142报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途