盐酸马尼地平 T0193

Product Introduction
Bioactivity


英文名: Manidipine dihydrochloride

描述: Manidipine dihydrochloride (Manidipine 2HCl) 是一种钙离子通道阻断剂，能抑制钙流，IC50=2.6 nM。

细胞实验: The mitogenic effect is measured by the amout of [3H]thymidine incorporated into DNA of human MCs and by assessment of cell proliferation. In brief, 1 × 105 quiescent cells is seeded into a 25-mL cell culture bottle and kept in low serum medium (0.1% FCS). On the following day, the cells are preincubated for 3 hours with Manidipine (10 nM) followed by stimulation with PDGF-BB (10 ng/mL) or incubated with low serum medium abone. The medium is replaced each day, and the cells are counted at days 1, 3 and 5.(Only for Reference)

体外活性: 在纳摩尔级浓度的Manidipine,能够有效调节参与系膜细胞促炎性变化的基因转录。Manidipine抑制冠状动脉(pIC50=9.3 nM)和肾动脉(pIC50=9.1 nM)。Manidipine在高于0.1 nM浓度时降低Ca2+流,在100 nM浓度时阻断Ca2+流。

体内活性: 在高血压大鼠中,口服 Manidipine（3 mg/kg和10 mg/kg）以剂量依赖性的方式降低大鼠的收缩压.Manidipine（10 mg/kg）给药1小时到3小时后,能够将血压降低到正常水平.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 60 mg/mL (87.77 mM)


关键字: Ca channels | Ca2+ channels | Manidipine dihydrochloride | CV4093 | Inhibitor | CV 4093 | Manidipine Dihydrochloride | Manidipine | inhibit | Calcium Channel

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相关库: Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Anti-Hypertension Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library

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