匹格列酮盐酸盐 T0214L
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 112529-15-4 | ¥218.00 | 询底价 |
50 mg | 112529-15-4 | ¥155.00 | 询底价 |
500 mg | 112529-15-4 | ¥570.00 | 询底价 |
100 mg | 112529-15-4 | ¥198.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pioglitazone hydrochloride
描述: Pioglitazone hydrochloride (AD 4833) 是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ,EC50分别为 0.93 和 0.99 μM。它是一种口服活性噻唑烷二酮的盐酸盐,具有抗糖尿病特性和潜在的抗肿瘤活性。
细胞实验: In order to evaluate cell proliferation, HIT-T15 cells are seeded on 96-well plates (3×104 cells/well) and cultured for 5 days as described. Viable cells are determined using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay. To evaluate cell apoptosis and cell necrosis, HIT-T15 cells are plated on 6-well dishes (7×105 cells/well) for 5 days in standard conditions (CTR) or in the presence of AGEs (AGEs) with or without Pioglitazone (0.5 or 1 μM) or AG (1 mM). They are then processed to measure both the activity of caspase-3 and the activity of lactate dehydrogenase (LDH) (a stable cytosolic enzyme that is a marker of cell membrane damage and cell death due to necrosis) using Cytotox 96 Non Radioactive Cytotoxicity Assay[2].
体外活性: 在雄性肥胖鼠中,口服 Pioglitazone(0.3-3 mg/kg)7天,能够以剂量依赖性的方式地降低高血糖症,高脂血症,和高胰岛素血症.
体内活性: Pioglitazone 通过抑制iNOS的表达和NO的产生,保护多巴胺能神经元被LPS损伤。Pioglitazone也能够抑制脂多糖诱导的p38蛋白磷酸化。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (127.26 mM)
关键字: Pioglitazone hydrochloride | PPAR | Ferroptosis | Inhibitor | Pioglitazone | inhibit | AD-4833 | Pioglitazone Hydrochloride | Peroxisome proliferator-activated receptors | AD4833
相关产品: NADPH tetrasodium salt | Vamifeport | DL-Buthionine-(S,R)-sulfoximine | Baicalein | Piperazine Erastin | Brusatol | L-Glutamic acid monosodium salt | FIN56 | Imidazole ketone erastin | GPX4-IN-7
相关库: Anti-Aging Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Hematopoietic Toxicity Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途