盐酸倍他司汀 T0246

Product Introduction
Bioactivity


英文名: Betahistine dihydrochloride

描述: Betahistine dihydrochloride (Betahistine 2HCl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。

体外活性: 在小鼠中,Betahistine（ED50=2 mg / kg）以剂量依赖性方式增加t-MeHA水平.在美尼尔病患者中,Betahistine（16 mg,每天两次,持续3个月）,对于眩晕有明显的缓解效果.Betahistine（50 mg / kg）诱导猫脑部的结节性乳头状核中组氨酸脱羧酶mRNA的上调.

体内活性: 在3 μM毛喉素处理的CHO(H3R)细胞中,Betahistine可以渐进性地增加 cAMP形成,在10 nM时达到最大效果。在CHO(H3R)细胞中,Betahistine 渐进性地降低A23187诱发的 [3H]花生四烯酸释放 （EC50=0.1 nM）,在30 nM 时效果最好。

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (239.1 mM)
H2O : 35 mg/mL (167.4 mM)
Ethanol : 1 mg/mL (4.78 mM)


关键字: PT9 | arthritis | antipsychotic | Rheumatoid | inhibit | Betahistine Dihydrochloride | Histamine Receptor | schizophrenia | episode | Betahistine dihydrochloride | Ménière | CIA | Inhibitor | Betahistine | PT 9 | disease

相关产品: Promethazine | Rhodiocyanoside A | Hydroxyzine Pamoate | Impromidine hydrochloride | Fexofenadine hydrochloride | Dimenhydrinate | HTMT dimaleate | Chlorphenoxamine | Mizolastine | Cetirizine D4

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | Orally Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途