丙氯拉嗪 T0385

Product Introduction
Bioactivity


英文名: Prochlorperazine Maleate

描述: Prochlorperazine Maleate (Capazine) 是一种吩噻嗪类抗精神病药，主要用于治疗恶心、呕吐和眩晕。它比氯丙嗪更容易引起锥体外系疾病。

细胞实验: Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.(Only for Reference)

体外活性: Prochlorperazine 通过下调cyclin E2表达抑制对他莫昔芬(tamoxifen)有抗性的MCF-7细胞的增殖。Prochlorperazine 具有影响雌激素受体(estrogen receptor, ER)功能的潜力，且可能改变内分泌治疗的反应[2]。

体内活性: Prochlorperazine 在小鼠中可以诱导抗痛觉效应。经Prochlorperazine处理后的小鼠在转棒试验中显示出完整的运动协调能力，保持了正常的自发移动性和通过孔板测试显示的探索行为。[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 2 mg/mL (3.3 mM)
DMSO : 15.2 mg/mL (25 mM)


关键字: Prochlorperazine Maleate | Prochlorperazine | Prochlorperazine Dimaleate

相关产品: Zuclopenthixol | 5,7-Dimethoxyluteolin | Amitifadine hydrochloride | Nomifensine maleate | Dimethocaine | D1R antagonist 1 | Loxapine | Ansofaxine hydrochloride | CCG 203769 | Trazpiroben

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Bioactive Compound Library

丙氯拉嗪 T0385信息由TargetMol中国为您提供，如您想了解更多关于丙氯拉嗪 T0385报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途