盐酸胍 T0415

Product Introduction
Bioactivity


英文名: Guanidine hydrochloride

描述: Guanidine hydrochloride (Aminoformamidine Hydrochloride) 是一种强离液剂和一种蛋白质的强变性剂。

体外活性: Guanidine HCl 是一种蛋白质变性剂。[1] 低浓度Guanidine HCl 能够重塑酸性展开的肌红蛋白和细胞色素c，稳定熔融球状态。[2] Guanidine HCl 展开核糖核酸酶的效果是尿素的2.8倍，但对溶菌酶仅是1.7倍。不同蛋白质在特定pH值下Guanidine HCl 的△GWaterapp.值分别为：核糖核酸酶 9.7 Cal/mole（pH 6.6）、溶菌酶 6.1（pH 2.9）、α-胰蛋白酶 8.3 （pH 4.3）、以及β-乳球蛋白11.7（pH 3.2）。[3] Guanidine HCl 能够有效消除酵母细胞中的[PSI+]元素。5 mM Guanidine HCl 的生长培养基能抑制酵母的[PSI+]及其它朊病毒的[PSI+]。[4] Guanidine HCl 降低了Hsp104恢复热变性荧光素酶活性的能力。[5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (523.4 mM)
H2O : 198.9 mM


关键字: unfolded | Endogenous Metabolite | Guanidinium Chloride | Hsp104 | chaotrope | Guanidine hydrochloride | denaturant | Guanidinium | Guanidine | Aminoformamidine | Inhibitor | Guanidine Hydrochloride | inhibit | proteins

相关产品: nor-NOHA acetate | L-Ornithine | BEC hydrochloride | Piceatannol 3'-O-glucoside | DL-Norvaline | Nor-NOHA monoacetate | Urea | OATD-02 | Nω-Hydroxy-nor-L-Arginine Dihydrochloride | ARG1-IN-1 hydrochloride

相关库: Drug Repurposing Compound Library | Human Endogenous Metabolite Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途