赖诺普利二水合物 T0706

Product Introduction
Bioactivity


英文名: Lisinopril dihydrate

描述: Lisinopril dihydrate （MK-521) 是一种血管紧张素转化酶抑制剂。Lisinopri dihydrate 能够作用于高血压，充血性心力衰竭和心脏病等。

体外活性: Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. [1] Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. [2]

体内活性: Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. [3] Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. [4] Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. [5] Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. [6]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mM
DMSO : Insoluble


关键字: Inhibitor | inhibit | MK521 | Lisinopril dihydrate | Angiotensin-converting Enzyme (ACE) | MK-521 dihydrate | MK-521 | Lisinopril Dihydrate | MK 521

相关产品: TRV-120027 acetate (1234510-46-3 free base) | Aliskiren hemifumarate | Delapril hydrochloride | (Sar¹)-Angiotensin II acetate | Plantainoside D | N-Acetyl-Ser-Asp-Lys-Pro | OPHIOPOGONIN D | Losartan | Sinapinic Acid | Angiotensin II (3-8), human

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | FDA-Approved & Pharmacopeia Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Endocrinology-Hormone Compound Library | Target-Focused Phenotypic Screening Library | Preclinical Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途