舒洛地尔 T0712

Product Introduction
Bioactivity


英文名: Suloctidil

描述: Suloctidil 是一种外周血管扩张剂，作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性，可治疗痴呆和血栓形成病症。

激酶实验: Protein Kinase profiling assay: Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (148.12 mM)


关键字: Suloctidil | Inhibitor | Na+/K+ ATPase | inhibit | Sodium potassium pump

相关产品: Diphyllin | Strophanthidin | Cycloartane-3,24,25-triol | Matairesinol | Diazoxide | Cabraleadiol | Mitiglinide Calcium | Tegoprazan | Echinatine | Deslanoside

相关库: Ion Channel Inhibitor Library | Anti-COVID-19 Compound Library | ReFRAME Related Library | Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途