化合物24-Norursodeoxycholic acid T10087

Product Introduction
Bioactivity


英文名: 24-Norursodeoxycholic acid

描述: 24-Norursodeoxycholic acid (nor-UDCA) 是一种侧链缩短的 UDCA 的 C23 同系物，表现出有效的抗胆汁淤积，抗炎和抗纤维化活性。

体外活性: 24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes.?24-norUrsodeoxycholic acid underwent extensive phase I/II metabolism (hydroxylation, sulfation, and glucuronidation), thereby increasing the hydrophilicity of biliary bile acid secretion.?There was a coordinated induction of bile acid detoxifying enzymes (Cyp2b10, Cyp3a11, and Sult2a1) and efflux pumps (Mrp3 and Mrp4).?Ursodeoxycholic acid, in contrast, increased alanine transaminase and alkaline phosphatase levels, had no significant effects on hydroxyproline content, and induced biliary transporters and detoxification enzymes to a much smaller extent than 24-norUrsodeoxycholic acid.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (264.17 mM)


关键字: 24Norursodeoxycholic acid | Inhibitor | Norucholic acid | 24 Norursodeoxycholic acid | inhibit | 24-Norursodeoxycholic acid

相关库: Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Fibrosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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