化合物 T10236 T10236
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1410809-37-8 | ¥22,500.00 | 询底价 |
2 mg | 1410809-37-8 | ¥2,940.00 | 询底价 |
100 mg | 1410809-37-8 | ¥31,500.00 | 询底价 |
25 mg | 1410809-37-8 | ¥17,300.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ACHN-975 TFA
描述: ACHN-975 TFA is a selective LpxC inhibitor with a subnanomolar inhibitory. It is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL).
动物实验: Animal Model: Neutropenic mouse thigh model with P. aeruginosa ATCC 27853. Dosage: 5-30 mg/kg. Administration: i.p.; single dose [2]
体外活性: ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively [1].ACHN-975 is potently against the P. aeruginosa isolates tested, inhibiting 100% of the isolates at a MIC of ≤2?μg/ml. It against Pseudomonas aeruginosa with an MIC50 and MIC90 of 0.06 and 0.25?μg/ml, respectively. ACHN-975 is against six P. aeruginosa isolates, it against P. aeruginosa APAE1064, APAE1232, and APAE1064 isolates with MIC values of 0.12, 0.06, and 0.06 ?μg/ml, respectively [2].
体内活性: ACHN-975 TFA (i.p.; 5-30?mg/kg; single dose) leads to a steady reduction in bacterial titers in the first 4?h following treatment for all dosing groups. The sampling shows that the level of free drug in this model drops below the ACHN-975 MIC for this isolate (0.25?μg/ml) by 2?h after treatment with the 10 mg/kg dose and by 4?h after treatment with the 30 mg/kg dose [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: ACHN-975 TFA | ACHN975 TFA | ACHN 975 TFA
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途