盐酸奥昔布宁 T1049

Product Introduction
Bioactivity


英文名: Oxybutynin chloride

描述: Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物，用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道，IC50为 11.51 μM。

体外活性: Oxybutynin chloride 通过减少膀胱肌肉痉挛缓解尿频、尿急以及尿失禁（急迫性失禁）等泌尿系统和膀胱障碍。Oxybutynin chloride 与胆碱能受体的M1、M2和M3亚型呈竞争性拮抗作用。[1] 此外，Oxybutynin chloride 还能作为钙拮抗剂和局部麻醉剂，直接对膀胱平滑肌产生松弛作用，但该效应出现的浓度远高于临床使用浓度。[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 73 mg/mL (185.3 mM)
DMSO : 55 mg/mL (139.61 mM)
H2O : 4 mg/mL (10.15 mM)


关键字: Muscarinic acetylcholine receptor | Oxybutynin chloride | OAB | inhibit | KcsA | Kv channels | urinary frequency | Oxybutynin Chloride | Inhibitor | mAChR | Oxybutynin Hydrochloride | Potassium Channel | urinary incontinence | urinary urgency | Oxybutynin

相关产品: 3-Acetoxy-8(17),13E-labdadien-15-oic acid | Tamapin TFA | QO-40 | Mefloquine hydrochloride | 9-Hydroxycanthin-6-one | Dequalinium chloride | Amiodarone hydrochloride | Atpenin A5 | DCPIB | TWIK-1/TREK-1-IN-1

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Approved Drug Library | Drug Repurposing Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途