化合物 T10494 T10494

Product Introduction
Bioactivity


英文名: Beclomethasone 17-propionate

描述: Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.

体外活性: Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα, and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα, and CXCL8 were 0.05 nM, 0.01 nM, and 0.1 nM, respectively. Beclomethasone 17-propionate evokes the upregulation of the GR dependent genes FKBP51 and GILZ [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Beclomethasone 17-propionate | Beclomethasone | Beclomethasone 17 propionate | Beclomethasone 17propionate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途