化合物Bisindolylmaleimide VIII acetate T10549

Product Introduction
Bioactivity


英文名: Bisindolylmaleimide VIII acetate

描述: Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) 是一种选择性蛋白激酶 C 抑制剂。它促进 Fas 介导的细胞凋亡，并抑制 T 细胞介导的自身免疫性疾病。

体外活性: Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Bisindolylmaleimide VIII acetate (5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners. Bisindolylmaleimide VIII acetate (5 μM; 6 hours) significantly decreases procaspase-8 at 4 h and completely disappears at 6 h after the combined treatment with TRA-8 [2].

体内活性: Bisindolylmaleimide VIII acetate (100 μg; i.p.; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. The alone treatment with Bisindolylmaleimide VIII acetate does not induce significant tumor regression [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/ml (119.95 mM)


关键字: protein | Bisindolylmaleimide VIII acetate | Ro 31-7549 | Inhibitor | inhibit | Ro 31-7549 Acetate | Fas | Bis VIII | Apoptosis | autoimmune | Protein kinase C | diseases | kinase | cell-mediated | Bisindolylmaleimide VIII | Bisindolylmaleimide VIII Acetate | Bis VIII Acetate | PKC

相关产品: Schinifoline | UCF 101 | SW106065 | Busulfan | PU02 | Lucidenic acid B | Thrombospondin-1 (1016-1023) (human, bovine, mouse) | Troglitazone | SGI-1027 | LYN-1604

相关库: Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Epigenetics Compound Library | Apoptosis Compound Library | TGF-beta/Smad Compound Library | Reprogramming Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物Bisindolylmaleimide VIII acetate T10549信息由TargetMol中国为您提供，如您想了解更多关于化合物Bisindolylmaleimide VIII acetate T10549报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途