化合物Fostemsavir Tris T10570

Product Introduction
Bioactivity


英文名: Fostemsavir Tris

描述: Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。

体内活性: BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120.?BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates;?however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses.?The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions.?Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life.?

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (177.40 mM)
H2O : 100 mg/mL (141.92 mM)


关键字: Inhibitor | Fostemsavir Tris | inhibit | BMS 663068 | BMS663068 | HIV | Human immunodeficiency virus | Fostemsavir | BMS-663068

相关产品: Emivirine | Neotripterifordin | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride | AMD 3465 | Rilpivirine | HIV-1 integrase inhibitor 8 | IQP-0528 | Dolutegravir | Megestrol acetate | Cys-TAT(47-57) acetate(583836-55-9 Free base)

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Inhibitor Library | EMA Approved Drug Library | NO PAINS Compound Library | Covalent Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

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