化合物Casein Kinase II Inhibitor IV T10687
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 863598-09-8 | ¥7,380.00 | 询底价 |
50 mg | 863598-09-8 | ¥5,560.00 | 询底价 |
1 mg | 863598-09-8 | ¥598.00 | 询底价 |
25 mg | 863598-09-8 | ¥3,970.00 | 询底价 |
10 mg | 863598-09-8 | ¥2,560.00 | 询底价 |
500 mg | 863598-09-8 | ¥14,800.00 | 询底价 |
1 mL | 863598-09-8 | ¥1,900.00 | 询底价 |
5 mg | 863598-09-8 | ¥1,730.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Casein Kinase II Inhibitor IV
描述: Casein Kinase II Inhibitor IV 是一种小分子诱导剂,可诱导表皮角质形成细胞分化。
体外活性: Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expresses loricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL (69.85 mM)
关键字: Inhibitor | Casein Kinase | inhibit | Casein Kinase II Inhibitor IV
相关产品: Longdaysin | CK1-IN-3 | (E/Z)-GO289 | D4476 | A-3 hydrochloride | Casein kinase 1δ-IN-7 | TAK-715 | DMAT | Casein kinase 1δ-IN-10 | BMS-863233 HCl
相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途