化合物 T10688 T10688
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 414910-30-8 | ¥16,600.00 | 询底价 |
25 mg | 414910-30-8 | ¥12,700.00 | 询底价 |
100 mg | 414910-30-8 | ¥21,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Casopitant mesylate
描述: Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of antiemetics.
体内活性: In a ferret-model of Cisplatin-induced emesis, Casopitant inhibits retching and vomiting and reduced nausea-like behaviours in a dose-dependent manner. Following a single intraperitoneal dose, radioactive labeled Casopitant ([14C]Casopitant) is rapidly absorbed, with plasma and brain concentrations being approximately equal at two hours post-dosing. [14C]Casopitant is found in the brain as the parent compound and two major oxidative metabolites (M1 and M2), accounting for approximately 76%, 19%, and 3% of the radioactivity, respectively. Casopitant possesses a high affinity for brain NK1 receptors in the ferret [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Casopitant Mesylate | Casopitant mesylate
相关产品: Fenofibrate | Liarozole | 8alpha-Tigloyloxyhirsutinolide 13-O-acetate | Albaconazole | Curdione | Licopyranocoumarin | Lasiodin | AG 045572 | Piperine | Chrysosplenetin
化合物 T10688 T10688信息由TargetMol中国为您提供,如您想了解更多关于化合物 T10688 T10688报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途