化合物 T1087L T1087L
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 124832-26-4 | ¥10,600.00 | 询底价 |
100 mg | 124832-26-4 | ¥17,500.00 | 询底价 |
50 mg | 124832-26-4 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Valaciclovir
描述: Valacyclovir (Valaciclovir) 是一种具有口服活性的抗病毒药物,用于抑制单纯疱疹,带状疱疹和疱疹 B。Valacyclovir 抑制 HSV-1W (50=2.9 μg/ml)。Valacyclovir 是 Aciclovir 的前药。
体外活性: Valacyclovir (Valaciclovir; VACV) uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 mM and 23.34 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, which demonstrates that hPEPT1 dominates the intestinal transport properties of VACV in vitro [5].
体内活性: A large comparative trial has shown that Valacyclovir (1 g twice a day) is as same effective as acyclovir (200 mg five times a day) when given for 10 days for treatment of the first episode of genital herpes. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valacyclovir is as effective as 2 g daily. Valacyclovir can be administered once a day [1]. The concentrations of acyclovir in serum and CSF were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day [2]. EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01 ug/ml, while values in BHK cells were 0.2 and 0.03 ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA [3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Valaciclovir
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途