化合物 T10937 T10937
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1445179-97-4 | ¥9,570.00 | 询底价 |
Product Introduction
Bioactivity
英文名: D-JNKI-1
描述: D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.
体外活性: D-JNKI-1 (AM-111; 1μM-1mM) treatment can prevent neomycin-exposed hair cell apoptosis and loss.
体内活性: D-JNKI-1 (AM-111; 10μM) can prevent almost all hair cell death and permanent hearing loss caused by neomycin ototoxicity in guinea pig cochlea mp. Local delivery of D-JNKI-1 can also prevent permanent hearing loss caused by hearing trauma in a dose-dependent manner. D-JNKI-1 (0.3 mg / kg, intraperitoneal injection) reversed these pathological events in the rat brain mitochondria, almost completely eliminating the release of cytochrome c and the cleavage of PARP. D-JNKI-1 (1 μg / kg, s.c.) caused a significant decrease in the disease activity index and reduced the expression of CD4 + and CD8 + cells in mice.
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 50 mg/mL (13.08 mM)
关键字: D JNKI 1 | AM 111 | AM111 | D-JNKI-1 | XG102 | DJNKI1 | XG 102
相关产品: Lappaol F | JNK-1-IN-2 | Ganoderic acid X | beta-Asarone | Astragaloside IV | Decursinol angelate | (-)-Bornyl acetate | Desoxo-narchinol A | Vacquinol-1 | Arjunolic acid
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途