化合物 T10946 T10946
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 154229-21-7 | ¥1,480.00 | 询底价 |
Product Introduction
Bioactivity
英文名: D4-abiraterone
描述: D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an antagonist of androgen receptor.
体外活性: D4-Abiraterone (D4A) (10 mM) almost completely prevented the conversion of D4-androstenedione (AD) to 5α-androstanedione and other 5α-reducing androgens. D4-Abiraterone has greater affinity for androgen receptor (AR) than mutant (expressed in LNCaP, half maximum inhibitory concentration (IC50 = 5.3 nM)) and wild type (expressed in LAPC4, IC50 = 7.9 nM) Abiron (IC50 = 418 and> 500 nM, respectively). Compared with Abi, D4-abiraterone significantly inhibited the expression of PSA, TMPRSS2 and FKBP5 in LNCAP, LAPC4 and C4-2 cell lines. D4-Abiraterone also suppressed AR target gene expression in a dose-dependent manner.
体内活性: In preventing the conversion of 3β-hydroxysteroid dehydrogenase (3βHSD) from dehydroepiandrosterone (DHEA) to D4-androstenedione (AD) in LNCaP and VCaP xenografts, D4-Abiraterone (D4A) The effect is ten times higher than that of Abiron. In LNCaP and VCaP xenografts, AD accumulation was blocked at 48 h, and 0.1 μMD4-Abiraterone was equivalent to 1 μMAbi. Compared with the Abirate acetate group, the progress of the D4-Abiraterone group was significantly delayed (P = 0.011). Compared with abirate acetate, D4-Abiraterone treatment can increase progression-free survival .
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (143.89 mM)
关键字: D4-abiraterone | CB7627 | CB 7627 | D4abiraterone | D-4-abiraterone | D4 abiraterone | delta4-Abiraterone
相关产品: p,p'-DDE | Zanoterone | SK33 | RU 59063 | GSK-2881078 | Chlormadinone acetate | S-23 | MK-0773 FA | DSRM-3716 | BMS-641988
化合物 T10946 T10946信息由TargetMol中国为您提供,如您想了解更多关于化合物 T10946 T10946报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途