化合物 T11055 T11055

Product Introduction
Bioactivity


英文名: DL-TBOA

描述: DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA is an effective non-transportable excitatory amino acid transporter inhibitor with IC50 of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter 1 (EAAT1, EAAT2 and EAAT3), respectively.

体外活性: DL-TBOA reversed the loss of viability caused by oxaliplatin. DL-TBOA (350 μM; 24 hours; HCT116 and LoVo cell lines) treatment can reduce the induction of p53 by SN38 and oxaliplatin. DL-TBOA (70-350 μM; 48 hours; HCT116 and LoVo cell lines) treatment concentration-dependently enhanced SN38-induced loss of vitality.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: DL-TBOA | DLTBOA | DL TBOA

相关产品: Gentianine | Marein | Glutaminase-IN-1 | T-1095 | BPTES | BAY-876 | Jujuboside A | Nepodin | Brilliant Yellow | MSNBA

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途