化合物LHF-535 T11138L

Product Introduction
Bioactivity


英文名: LHF-535

描述: LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM

体外活性: LHF-535 is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein (GP). LHF-535 inhibits Lassa GP-pseudotyped lentivirus (IC50: 0.1-0.3 nM). LHF-535 shows effective antiviral activity against a broad array of hemorrhagic fever arenaviruses [2].

体内活性: An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection. LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protects mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 96.67 mg/mL (234.34 mM)
H2O : < 0.1 mg/mL (insoluble)


关键字: inhibit | Arenavirus | LHF535 | LHF 535 | Inhibitor | LHF-535

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相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Orally Active Compound Library | Anti-Viral Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途