达卡巴嗪 T1120
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 4342-03-4 | ¥695.00 | 询底价 |
100 mg | 4342-03-4 | ¥384.00 | 询底价 |
1 g | 4342-03-4 | ¥840.00 | 询底价 |
50 mg | 4342-03-4 | ¥232.00 | 询底价 |
1 mL | 4342-03-4 | ¥198.00 | 询底价 |
200 mg | 4342-03-4 | ¥494.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Dacarbazine
描述: Dacarbazine (DTIC-Dome) 是一种抗肿瘤剂,对黑色素瘤具有显着的活性。
细胞实验: Apotosis assay: UACC903 (UACC) cells treated with or without DTIC (20 μM) for 48 h are incubated with agonist anti-Fas Ab, CH-11 (500 ng/ml), for 5 and 16 h, respectively. To distinguish whether death/apoptosis is mediated by FasR, blocking anti-Fas Ab ZB4 (2 mg/ml) is added in the corresponding groups. At the end of incubation, cells are harvested and stained with propidium iodide and FITC-annexin V (BD PharMingen) for detecting apoptosis according to the instruction provided by the company. Ten thousand cells from each group are collected, and dead and apoptotic cells are analyzed without gating using CellQuest software. (Only for Reference)
体外活性: Dacarbazine 通过Fas非依赖途径介导的可以使黑色素瘤对特定肽CTL的溶解更为敏感[2]。
体内活性: Axitinib和Dacarbazine 联合治疗在对抗黑色素瘤侧方异种移植物方面展现了显著的抗肿瘤活性,能减少肿瘤细胞增殖,减小肿瘤坏死面积,并促进细胞凋亡。此外,Dacarbazine可降低与转移相关的因子,并延长小鼠的生命期[3]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 3 mg/mL (16.46 mM)
关键字: B cell | Apoptosis | Nucleoside Antimetabolite/Analog | Dacarbazine | inhibit | antineoplastic | Inhibitor | T cell | metastatic malignant melanoma
相关产品: VU 0364739 hydrochloride | Puromycin aminonucleoside | Rotenone | K858 (Racemic) | PARP-2-IN-3 | SKI-178 | MAZ51 | (Z)-Guggulsterone | Nortrachelogenin | Sacubitril/Valsartan
相关库: Drug Repurposing Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Traditional Chinese Medicine Monomer Library | Chemotherapy Drug Library | Anti-Infection Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途