化合物 T11400 T11400
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 334827-98-4 | ¥1,710.00 | 询底价 |
100 mg | 334827-98-4 | ¥14,400.00 | 询底价 |
25 mg | 334827-98-4 | ¥7,170.00 | 询底价 |
50 mg | 334827-98-4 | ¥9,320.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Gisadenafil besylate
描述: Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor ,prevents degradation of cyclic guanosine monophosphate (cGMP), with an IC50 of 3.6 nM .
体外活性: The IC50 of Gisadenafil for PDE5A is 3.6 nM. In contrast, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in specificity.Since some PDE5 inhibitors can also interact with PDE1 isotypes found within the cerebral vasculature, the specificity of Gisadenafil for PDE5 is confirmed.?This is directly tested with recombinant PDE5A and PDE1A overexpressed in COS-7 cells.
体内活性: Gisadenafil also restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Gisadenafil besylate
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途