化合物 T11446 T11446

Product Introduction
Bioactivity


英文名: GNF362

描述: GNF362 is a selective and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb; IC50: 9 nM). GNF362 also inhibits Itpka and Itpkc (IC50s: 20 nM and 19 nM).

体外活性: GNF362 augments SOC responses following antigen receptor cross-linking, with an EC50 of 12 nM in primary B or T lymphocytes.GNF362 (0-10 mM) blocks Ins (1,3,4,5) P4 production, enhances antigen receptor-driven Ca2+ responses and lead to apoptosis of activated T cells in an Itpkb-dependent manner in lymphocytes.

体内活性: GNF362 ?shows minimal block in antibody production but shows significant inhibition of joint swelling at 6 mg/kg, reduces inflammatory cell infiltrate, proteoglycan los, and sjoint damage?at 20 mg/kg.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (293.12 mM)


关键字: GNF 362 | GNF362 | GNF-362

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途