化合物 T11597L T11597L

Product Introduction
Bioactivity


英文名: IACS-9571 Hydrochloride (1800477-30-8 free base)

描述: IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).

体外活性: IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24.IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (184.03 mM)
H2O : 10 mg/mL (14.72 mM)


关键字: IACS 9571 Hydrochloride (1800477 30 8 free base) | 1800477-30-8 free base | IACS9571 Hydrochloride (1800477308 free base) | 1800477-30-8 | IACS 9571 Hydrochloride | ASIS-P 040 Hydrochloride | ASIS-P-040 Hydrochloride | IACS9571 Hydrochloride

相关产品: I-CBP112 | BAY1238097 | dBRD9 HCl | BRD4 Inhibitor-27 | CCT077791 | Crebinostat | ZXH-3-26 | BET-IN-15 | GNE-064 | Bromodomain inhibitor-12 (edisylate)

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途