化合物ICI 118,551 hydrochloride T11607
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 72795-01-8 | ¥383.00 | 询底价 |
1 mg | 72795-01-8 | ¥173.00 | 询底价 |
10 mg | 72795-01-8 | ¥699.00 | 询底价 |
1 mL | 72795-01-8 | ¥677.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ICI 118,551 hydrochloride
描述: ICI 118,551 hydrochloride (ICI 118551 hydrochloride) 是高度选择性的β2 adrenergic receptor 拮抗剂,能够结合 β2 肾上腺素能受体(Ki=0.7 nM)、β1 肾上腺素能受体 (Ki=49.5 nM) 和 β3 肾上腺素能受体 (Ki=611 nM)。
体外活性: ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO [2]. ICI 118551 inhibits cAMP accumulation in IMCD cells (IC50: 1.7 μM) [1]. In the failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances the negative inotropic effects of ICI 118551 [3].
体内活性: ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, strongly reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure in vivo[2].
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 20 mg/mL (63.72 mM)
H2O : 11 mg/mL (35.05 mM)
关键字: ICI118551 | ICI 118,551 hydrochloride | ICI 118551 | Adrenergic Receptor | ICI-118551 | ICI 118,551 Hydrochloride | Inhibitor | Beta Receptor | inhibit | ICI-118551 Hydrochloride | ICI 118,551 | ICI 118551 Hydrochloride | ICI118551 Hydrochloride
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相关库: Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | Highly Selective Inhibitor Library | Bioactive Compound Library
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