化合物JNJ-37822681 dihydrochloride T11722

Product Introduction
Bioactivity


英文名: JNJ-37822681 dihydrochloride

描述: JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。

体内活性: JNJ-37822681 dihydrochloride 在较低剂量下(ED50 = 0.39 mg/kg)即能占据大鼠大脑中的D2受体，并且在动物精神病模型中显示出效果（例如，抑制阿波吗啡引起的刻板行为或D-安非他明/苯环利定诱发的高活动性）[4]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 33.33 mg/mL (74.86 mM)


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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途