化合物 L-NIL T11805

Product Introduction
Bioactivity


英文名: L-NIL

描述: L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO synthase, respectively.

体外活性: The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS.

体内活性: L-NIL protects the integrity of the tarsal, talus and calcaneus bones as well as the soft tissue surrounding the joint, while adjuvant controls exhibit severe deterioration of these bones and dramatic soft tissue swelling.?L-NIL limits progression of preexisting atherosclerosis in hypercholesterolemic rabbits.?Increased intimal collagen accumulation may participate in iNOS-induced atherosclerosis progression.L-NIL may prove particularly useful in determining the role of nitric oxide production by inducible NOS in models of chronic inflammation (e.g., adjuvant arthritis).?L-NIL suppresses the increase in plasma nitrite levels and joint inflammation associated with adjuvant-induced arthritis in a dose-dependent manner.?L-NIL attenuates the inducible nitric oxide synthase immunoreactivity in adjuvant-treated rats.

存储条件: store at low temperature,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : < 1 mg/mL (insoluble or slightly soluble)


关键字: L NIL | LNIL | L-NIL

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途