化合物 T11958 T11958

Product Introduction
Bioactivity


英文名: MBM-17

描述: MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM). It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.

体外活性: MBM-17 (0.25-1.0 μM; 24 hours) induced G2/M phase arrest and accumulation of cells with >4N content. MBM-17 (0.5-1.0 μM; 24 hours) triggers apoptosis of cancer cells.MBM-17 (compound 42c) inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively.

体内活性: MBM-17 (1.0 mg/kg;?i.v.) treatment shows CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 42.4 mL/min/kg, 4.06 L/kg, 2.42 hours, 386 ng/h/mL, and 405 ng/h/mL, respectively.MBM-17 (20 mg/kg;?i.p.;?twice a day for 21 days) exhibits good antitumor activity and a well-tolerated dose schedule.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MBM 17 | MBM17 | MBM-17

相关产品: CCT129202 | JNJ-7706621 | Palmatine | Aurora B inhibitor 1 | SP-96 | CCT 137690 | Aurora kinase inhibitor-3 | ENMD-2076 | Alisertib | G-749

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途