化合物MRZ 2-514 T12110

Product Introduction
Bioactivity


英文名: MRZ 2-514

描述: MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) 是 NMDA receptor(glycineB) 的拮抗剂，Ki=33 μM。

体外活性: MRZ 2-514 抑制峰值AMPA诱导的电流，IC50值为72.7 μM[1]。

体内活性: MRZ 2-514在小鼠 MES模型中显示出抗惊厥作用，并且这种效应被probenecid加强[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 18.33 mg/ml (59.51 mM)


关键字: inhibit | Inhibitor | MRZ 2514 | MRZ 2-514 | MRZ 2 514 | iGluR | Ionotropic glutamate receptors

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途