哌拉西林钠 T1213

Product Introduction
Bioactivity


英文名: Piperacillin sodium

描述: Piperacillin sodium salt(CL227193) )是一种β-内酰胺类广谱抗生素。

激酶实验: Inhibition of Prostaglandin Formation: Recombinant COX-1 and COX-2 from rat (rCOX) and human (hCOX) expressed in a baculovirus system are purified and reconstituted with 2 mM phenol and 1 μM hematin. Then the cyclooxygenase activity is measured using a radiometric assay, and the specific activity of the final enzyme preparations used is between 20,000 and 35,000 units. Ketorolac (2 -15 μL) are diluted in DMSO and preincubated with the appropriate recombinant COX (3 -15 ng) at a final concentration of 0.01 to 1000 μM in a reaction mixture (150 μL) containing 50 mM Tris-HCl buffer (pH 7.9), 2 mM EDTA, 10% glycerol, 2 mM phenol, and 1 μM hematin for 10 minutes. The reaction is initiated by addition of [14C]arachidonic acid (50–60 mCi/mmol in a final concentration of 20 μM) and is terminated 45 seconds later by the addition of 100 μL of 0.2 N HCl and 750 μL of distilled water. The total reaction volume is then applied to a 1 mL C18 Sep-pak column that has previously been washed with 2 mL of methanol followed by 5 mL of deionized water. Oxygenated products are eluted with 3 mL of a mixture of acetonitrile/water/acetic acid (50:50:0.1, v/v/v) and quantified by liquid scintillation spectroscopy.

体内活性: Piperacillin对阳性/阴性革兰氏和需氧/厌氧细菌具有体外抗菌活性。Piperacillin通过与青霉素结合蛋白结合进行调节抑制细菌细胞壁合成。各种β-内酰胺酶,包括头孢菌素酶、青霉素酶以及广谱β-内酰胺酶均无法使Piperacillin水解。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 92 mg/mL (170.5 mM)
Ethanol : 93 mg/mL (172.4 mM)
DMSO : 93 mg/mL (172.4 mM)


关键字: Bacterial | CL 227193 | Piperacillin | Piperacillin sodium | Antibiotic | CL-227193 | Inhibitor | inhibit

相关产品: Closantel | Halazone | Clarithromycin | Sultamicillin Tosylate | (+)-δ-Cadinene | Elubiol | Carabrone | Sulfanitran | Bisdionin C | Lenampicillin hydrochloride

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | Drug-induced Liver Injury (DILI) Compound Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Beta-Lactam Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途