化合物NBDHEX T12189

Product Introduction
Bioactivity


英文名: NBDHEX

描述: NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂，也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡，通过抑制 GST 的催化活性，避免抑制剂被特异性泵从细胞中排出，以及破坏 GSTP1-1和关键信号传导因子之间的相互作用，从而起到抗癌的作用。

体外活性: NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1;?LC(50) of 4.5 +/- 0.9 micromol/L).?Drug efflux experiments, done in the presence of a specific inhibitor of MRP1, confirmed that NBDHEX is not a substrate for this export pump [1].

体内活性: NBDHEX, In female mice, treatment results in a statistically significant tumour inhibition (approximately 70%) [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (420.41 mM)


关键字: inhibit | Glutathione Peroxidase | Autophagy | c-Jun | catalytic | anticancer | Inhibitor | GSSG | Apoptosis | JNK | NBDHEX | p38MAPK | cytotoxic | extrusion

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相关库: Glutamine Metabolism Compound Library | Anti-Cancer Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Apoptosis Compound Library | Autophagy Compound Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途