化合物NS8593 hydrochloride T12256

Product Introduction
Bioactivity


英文名: NS8593 hydrochloride

描述: NS8593 hydrochloride (NS8593 HCl) 是选择性的 SK 通道抑制剂。它可逆抑制 SK3介导的电流，Kd 值为 77 nM。它抑制所有 SK1-3亚型的 Ca2+依赖性 (在 0.5 μM Ca2+时，Kd 分别为 0.42、0.60 和 0.73 μM)，并且不影响中间电导和大电导的钙激活钾通道。

体外活性: It is found that tested in excised patches, the inhibition by NS8593 (compound 14) decreased as the intracellular [Ca2+] is increased and that NS8593 is equipotent when applied from either the intracellular or the extracellular side of the cell membrane.?A HEK293 cell transiently transfected with hSK3 channels is inhibited by 80% upon application of 100 nM apamin and by 75% after application of 300 nM NS8593.

体内活性: NS8593 is able to affect firing pattern and firing rate?of dopaminergic neurons in vivo in C57Bl/6 mice[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 80 mg/mL (266.84 mM)


关键字: NS8593 hydrochloride | inhibit | NS8593 | neurological | Ca2+ | NS 8593 Hydrochloride | Inhibitor | hIK | SK1 | SK2 | KcsA | Potassium Channel | NS-8593 Hydrochloride | NS-8593 | SK3 | hBK | NS8593 Hydrochloride | neurons | NS-8593 hydrochloride | dopaminergic | NS 8593 | channel

相关产品: ML418 | Phrixotoxin-1 | Endoxifen Z-isomer hydrochloride | Paederosidic acid methyl ester | Hongotoxin-1 | GAL-021 sulfate | Iptakalim Hydrochloride | ML335 | TWIK-1/TREK-1-IN-3 | NS5806

相关库: Ion Channel Inhibitor Library | Potassium Channel Blocker Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

化合物NS8593 hydrochloride T12256信息由TargetMol中国为您提供，如您想了解更多关于化合物NS8593 hydrochloride T12256报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途