化合物 T12418 T12418

Product Introduction
Bioactivity


英文名: PF-04217903 phenolsulfonate

描述: PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).

体外活性: PF-04217903 phenolsulfonate inhibits proliferation of c-Met–amplified human GTL-16 gastric carcinoma and H1993 NSCLC cells with IC50 values of 12 and 30 nM, respectively[1].

体内活性: PF-04217903 phenolsulfonate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 phenolsulfonate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors.PF-04217903 phenolsulfonate dose dependently inhibits c-Met, Gab-1, Erk1/2, and AKT phosphorylation and induced apoptosis (cleaved caspase-3) in U87MG xenograft tumors at all dose levels.[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: PF04217903 phenolsulfonate | PF 04217903 phenolsulfonate | PF-04217903 phenolsulfonate

相关产品: Crizotinib hydrochloride | MET/PDGFRA-IN-1 | PF-04217903 | Bozitinib | SYN1143 | CSF1R-IN-2 | SRI 31215 TFA | Golvatinib | RPI-1 | BMS-2

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途