匹伐加宾 T12492

Product Introduction
Bioactivity


英文名: Pivagabine

描述: Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。它可穿透大鼠的血脑屏障，拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。

动物实验: Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2].

体内活性: Pivagabine（CXB 722）（200 mg/kg；腹腔注射；每天两次，连续四天，并在第五天处死前1小时）可阻止足底电击应激对两个脑区CRF浓度的影响[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 49 mg/mL (261.69 mM)


关键字: blood-brain | γ-Aminobutyric acid Receptor | Pivagabine | psychoactive | derivative | Inhibitor | inhibit | foot | factor | barrier | CXB722 | shock | Gamma-aminobutyric acid Receptor | CXB 722 | GABA Receptor | neuromodulatory | corticotropin-releasing

相关产品: Loreclezole | Etifoxine hydrochloride | (-)-α-Pinene | Bifenazate | α-Thujone | 3-Methylglutaconic acid | Fengabine | SCH 50911 hydrochloride | Baclofen hydrochloride | Tiagabine hydrochloride

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Human Metabolite Library | Anti-Cancer Clinical Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途