化合物 T12826 T12826

Product Introduction
Bioactivity


英文名: SA57

描述: SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).

体外活性: SA57 exhibits clear time-dependent inhibition of FAAH and MAGL, suggesting a covalent mechanism of inactivation, presumably through carbamylation of the active site serine nucleophiles of these enzymes[1].

体内活性: In vivo SA57 (0.01-12.5 mg/kg; intraperitoneal injection; for 2 hours; C57Bl/6 mice) treatment shows distinct dose-responsive activity against brain serine hydrolases (FAAH, MAGL and ABHD6)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: SA-57 | SA57 | SA 57

相关产品: PDP-EA | Dual FAAH/sEH-IN-1 | ARN272 | FAAH-IN-2 | JNJ-1661010 | 2-Chlorophenylboronic acid | CB2R/FAAH modulator-1 | CB2R/FAAH modulator-3 | CB2R/FAAH modulator-2 | Biochanin A

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途