化合物 T13040 T13040

Product Introduction
Bioactivity


英文名: SUN 1334H

描述: SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).

体外活性: In CHO-K1/hERG cells,SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum(IC50 : 0.198 μM)[2].

体内活性: In beagle dogs and ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: SUN 1334H

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途