三氯生 T1314
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 3380-34-5 | ¥418.00 | 询底价 |
50 mg | 3380-34-5 | ¥254.00 | 询底价 |
500 mg | 3380-34-5 | ¥970.00 | 询底价 |
1 mL | 3380-34-5 | ¥385.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Triclosan
描述: Triclosan (Irgasan) 是一种在消费类产品中发现的抗菌剂和抗真菌剂,如肥皂, 洗涤剂, 玩具, 和手术清洗用品。
细胞实验: CV-1 cells are maintained in DMEM supplemented with 10% FBS, seeded in 96-well plates, and transfected with an expression vector containing a specific nuclear receptor and RXR, along with a luciferase reporter containing the appropriate DNA response element. The assay is first validated with known nuclear receptor ligands as positive controls. For the CAR ligand-binding assay, CV-1 cells are transiently transfected with the expression vector containing the Gal4 DNA-binding domain fused with the ligand-binding domain of murine or human CAR and cotransfected with the luciferase reporter plasmid, mh 100-luc. The day after the transfection, the positive compound of each nuclear receptor or TCS(Triclosan) is added and the cells are incubated for an additional 24 h. The luciferase activities are measured and normalized by β-gal activity.(Only for Reference)
体外活性: 在生理相关浓度下,用Triclosan处理的癌细胞显著增加了通过肿瘤形成评估的癌细胞群体数量。Triclosan处理的细胞呈现出类间充质样的形态,并减少了细胞间的黏附。这些细胞在降低E-钙黏蛋白的同时,明显上调了EMT标志物,包括N-钙黏蛋白、波形蛋白、蜗牛和鼻涕虫。Triclosan可能通过EMT过程,促进癌细胞在分离状态下的生存和移动能力[2]。
体内活性: Triclosan 在促进组织纤维化方面发挥病理作用,导致肝癌发生。Triclosan不仅加快了小鼠肝细胞癌(HCC)的发展,还对肝脏损伤的长期影响有所促进。Triclosan促进细胞纤维化和发生炎症[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (189.96 mM)
Ethanol : 57 mg/mL (196.86 mM)
关键字: Antibiotic | inhibit | Autophagy | Fungal | Inhibitor | Bacterial | Triclosan
相关产品: AKR1C3-IN-1 | Carvedilol phosphate hemihydrate | Dicoumarol | 2-HBA | Metronidazole | GLX351322 | Nucleocidin | ASP-9521 | Diphenyleneiodonium chloride | Acetohexamide
相关库: Anti-Aging Compound Library | Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途