化合物 T13146 T13146
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1018454-97-1 | ¥10,600.00 | 询底价 |
25 mg | 1018454-97-1 | ¥8,160.00 | 询底价 |
100 mg | 1018454-97-1 | ¥16,500.00 | 询底价 |
2 mg | 1018454-97-1 | ¥1,670.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Thienopyridone
描述: Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase(IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively), and induces p130Cas cleavage and apoptosis and has anticancer effects.
体外活性: in soft agar, Thienopyridone shows significant inhibition of tumor cell anchorage-independent growth (EC50 of the Thienopyridone are 3.29 μM and 3.05 μM for RKO and HT-29 cells, respectively). Thienopyridone (1-75 μM; 24 hours; HeLa cells) treatment shows a dose-dependent down-regulation of total p130Cas in HeLa cells. Thienopyridone induces p130Cas and FAK cleavage leads to caspase-mediated cell apoptosis. the cleavage of PARP and caspase-8 induced by Thienopyridone. Thienopyridone (3.75-30 μM; 24 hours) significantly suppresses HUVEC migration but not proliferation.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Thienopyridone
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途