化合物 T13328 T13328

Product Introduction
Bioactivity


英文名: AE0047 Hydrochloride

描述: AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.

体外活性: AE0047 Hydrochloride (4e) is an antagonist of calcium[1]. AE0047 inhibits [3H]nimodipine binding to rat cardiac membrane homogenate (IC50 of 0.26 nM)[2]. AE0047 (1 μM) inhibits the high K+-evoked vascular smooth muscle contraction, and also inhibits [3H]PN200-110 binding (Ki : 40.9 nM)[3].

体内活性: AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure(ED30 of 1.1 mg/kg)[2].In aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP), AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine [4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: AE 0047 Hydrochloride | AE-0047 Hydrochloride | AE0047 Hydrochloride

相关产品: Butamben | L-Phenylalanine-15N | Z944 | TTA-A8 | Dopropidil | RO2959 Hydrochloride | GSK-7975A | Temiverine hydrochloride | TTA-A2 | Tiapamil hydrochloride

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途