化合物Zamicastat T13383

Product Introduction
Bioactivity


英文名: Zamicastat

描述: Zamicastat (BIA 5-1058) 是多巴胺 β-羟化酶 (DBH) 抑制剂，可透过血脑屏障引起中枢和周边效应，具有降血压作用。它也是一种浓度依赖性的双重 P-gp 和 BCRP 抑制剂，IC50值分别为 73.8 和 17.0 μM。

体内活性: In the Dahl SS rat, Zamicastat (10, 30 and 100 mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 150 mg/mL (373.63 mM)


关键字: ABCB1 | Dopamine β-monooxygenase | Inhibitor | Cluster of differentiation 243 | ABCG2 | inhibit | P-glycoprotein | Multidrug resistance protein 1 | BCRP | MDR1 | CD243 | Breast cancer resistance protein | P-gp | Pgp | Zamicastat | Dopamine β-hydroxylase | Dopamine beta-hydroxylase | Dopamine beta-monooxygenase

相关产品: Brevianamide F | Triclabendazole sulfoxide | CP-100356 hydrochloride | ABCG2-IN-1 | Fumitremorgin C | GS-9191 PM | ABCG2-IN-2 | KS176 | YHO-13177 | Ko 143

相关库: Ion Channel Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Metabolism Compound Library | Anti-Cardiovascular Disease Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途