化合物 T13431 T13431

Product Introduction
Bioactivity


英文名: β-Apo-13-carotenone

描述: β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

体外活性: In homogenates of intestinal mucosa of rat, β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene. β-apo-13-carotenone is antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα[1]. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 33.33 mg/mL (128.99 mM)


关键字: β Apo 13 carotenone | β-Apo-13-carotenone | beta-Apo-13-carotenone | b-Apo-13-carotenone | βApo13carotenone

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途