R-雌马酚 T13443

Product Introduction
Bioactivity


英文名: (R)-Equol

描述: (R)-Equol ((+)-Equol) 是一种 ERα (Ki:27.4 nM) 和 Erβ (Ki:15.4 nM) 激动剂。

体外活性: (R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) [2].

体内活性: 在动物体内，与对照组相比，(R)-Equol 可显著减少可触及肿瘤的数量（P=0.002）。此外，摄食(R)-Equol的每只大鼠形成的可触及肿瘤数量明显少于S-(-)equol处理的大鼠（P=0.008）。摄食(R)-Equol的动物的肿瘤数量比对照组少43%，这一差异在统计学上极为显著（P=0.004）。摄食(R)-Equol的动物每个带瘤动物的肿瘤数量显著低于对照组（3.3±0.4比5.5±0.5, P=0.004）。尸检时，摄食(R)-Equol的大鼠的平均肿瘤重量（±标准误）（5.3±1.1 mg）显著减轻（P=0.04），与对照组（9.9±1.4 mg）相比。摄食(R)-Equol饮食可显著延长肿瘤潜伏期（P=0.003）[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (412.76 mM)


关键字: (R)-Equol | (R) Equol | Equol | (R)Equol | Inhibitor | Estrogen Receptor/ERR | inhibit

相关产品: ERRα antagonist-1 | Prinaberel | Mifepristone | FLTX1 | Uralenol | (±)-Equol | Estradiol | Isopsoralenoside | Endoxifen E-isomer hydrochloride | Glabrene

相关库: Bioactive Compounds Library Max | Human Metabolite Library | Nuclear Receptor Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途