β-榄香烯 T13476

Product Introduction
Bioactivity


英文名: β-Elemene

描述: β-Elemene (Levo-β-elemene) 是从植物姜黄中提取的一种天然产物，可以诱导细胞凋亡，具有抗肿瘤活性。

细胞实验: Cell viability assay was used to assess the resistance of SGC7901/ADR cells and the cytotoxic effects of β-Elemene.?Wound healing, transwell assay and lung metastatic mice model were used to the anti-metastasis effects of β-Elemene.?MicroRNA microarray analysis was used to explore potential regulated miRNAs.?Luciferase reporter assay was used to identify the direct target.?Human MMP antibody array, western blot, immunoprecipitation, qRT-PCR analyses and immunohistochemistry were conducted to investigate the underlying anti-metastasis mechanism of β-Elemene[3].

体外活性: β-Elemene 显著抑制了多药耐药性(MDR)胃癌细胞的体内外转移能力。从作用机理上看，β-Elemene 调控了 MMP-2/9 的表达，并逆转了上皮间质转化。β-Elemene 通过抑制 miR-1323 的表达上调了 Cbl-b，从而抑制了调控 MMP-2/9 的 EGFR-ERK/AKT 信号通路。在裸鼠模型中，β-Elemene 处理后肺部转移性肿瘤结节的数量显著减少。β-Elemene 通过调节 miR-1323/Cbl-b/EGFR 信号轴抑制了 MDR 胃癌细胞的转移[3]。

存储条件: store under nitrogenPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (244.68 mM)


关键字: Levo-b-elemene | Apoptosis | Inhibitor | beta-Elemene | inhibit | Levo-beta-elemene | β Elemene | βElemene | β-Elemene | b-Elemene

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相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Tobacco Monomer Library | Anti-Cancer Drug Library | Chinese Pharmacopoeia Natural Product Library | The Yao nationality medicine Library | Anti-Cancer Clinical Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Miao medicine Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途