6-羟基嘌呤 T1362

Product Introduction
Bioactivity


英文名: Hypoxanthine

描述: Hypoxanthine (Purin-6-ol)，也被称为 purine-6-ol 或 Hyp，是一种天然存在的嘌呤衍生物，是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下，Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤，黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。

体外活性: Hypoxanthine 是一种天然存在的嘌呤衍生物。作为核酸的组成部分，它偶尔在tRNA的反密码子中以其核苷形态--肌苷的形式出现。Hypoxanthine是一些特定细胞、细菌和寄生虫培养中不可或缺的添加物，用作底物和氮源。[1]

体内活性: A linear increase of plasma hypoxanthine with duration of hypoxemia is found in pigs, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. Moreover, there is a direct relationship between survival time and an increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62). All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine, thus, reflected the prognosis of acute hypoxia in contrast to base deficit[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : Insoluble
DMSO : 5 mg/mL (36.73 mM)


关键字: Endogenous Metabolite | Hypoxanthine | inhibit | Inhibitor

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