硝酸硫胺 T13923

Product Introduction
Bioactivity


英文名: Thiamine nitrate

描述: Thiamine nitrate (Vitamin B1 nitrate) 是必不能够少的维生素，能够提高正常的神经元活性。

体外活性: In the blood of homozygous KO and KI mice , Thiamine levels fed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively, at 7 weeks compared to WT mice (0.796±0.259 μM). When WT and homozygous KO and KI mice are fed a Thiamine-restricted diet (Thiamine: 0.60 mg/100 g food), blood Thiamine concentration at 5 and 14 days is markedly decreased to 0.010±0.009 and 0.010±0.006 μM, respectively, compared to WT mice (0.609±0.288 μM). Thiamine concentration in brain homogenate of WT mice fed a conventional diet is 3.81±2.18 nmol/g wet weight, and that of KO and KI is 1.33±0.96 and 2.16±1.55 nmol/g wet weight, respectively. It is worth noting that Thiamine concentration in brain homogenate decreases steadily in KO and KI mice fed a thiamine-restrict diet (Thiamine: 0.60 mg/100 g food) for 5 days (0.95±0.72 nmol/g wet weight) and 14 days (1.11±0.24 nmol/g wet weight), respectively, compare to WT (3.65±1.02 nmol/g wet weight), before the mice presenting an phenotype of disease[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.62 mg/mL (14.1 mM)


关键字: Vitamin B 1 | Vitamin B-1 | Thiamine Nitrate | Inhibitor | Vitamin B1 Nitrate | Thiamine | Endogenous Metabolite | Thiamine nitrate | Vitamin B1 | inhibit

相关库: Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Human Metabolite Library | Microbial Natural Product Library | Orally Active Compound Library | Gut Microbial Metabolite Library | RO5 Drug-like Natural Product Library | Natural Product Library

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