化合物5Z-7-Oxozeaenol T14055

Product Introduction
Bioactivity


英文名: 5Z-7-Oxozeaenol

描述: 5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂，不可逆的选择性抑制 TAK1和 VEGF-R2，IC50值分别为 8 nM 和 52 nM。

体外活性: 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (110.38 mM)


关键字: Vascular endothelial growth factor receptor | L 783279 | Antibiotic | MAP kinase kinase kinase, MEKK, MAPKKK | inhibit | 5Z7Oxozeaenol | L-783279 | FR 148083 | FR-148083 | VEGFR | 5Z 7 Oxozeaenol | 5Z-7-Oxozeaenol | Inhibitor | MAP3K

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途