化合物ACT-678689 T14119

Product Introduction
Bioactivity


英文名: ACT-678689

描述: ACT-678689 (Compound Example 1.53.4) 是一种色氨酸羟化酶 (TPH) 抑制剂，IC50=8 nM。

体外活性: TPH comprises two isoforms: TPH1 and TPH2. TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1]. TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 120 mg/mL (212.37 mM)


关键字: Tryptophan Hydroxylase | Inhibitor | ACT 678689 | ACT678689 | ACT-678689 | inhibit

相关产品: Mildronate | EWP 815 | Ketoconazole | GSK180 | Casein | Zamicastat | Telotristat ethyl | Diethyl-pythiDC | Rodatristat ethyl | Nepicastat hydrochloride

相关库: Bioactive Compounds Library Max | Inhibitor Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途