化合物β-NETA T14194

Product Introduction
Bioactivity


英文名: β-NETA

描述: β-NETA(α-NETA) 是胆碱乙酰转移酶(ChA；IC50=76 μM) 和胆碱酯酶 (ChE;IC50=40 µM)的非竞争性抑制剂，对乙酰胆碱酯的作用微弱 (AChE;IC50=1 mM)。

体外活性: a-NETA treatment increases EOC cell expression of pyroptosis-associated proteins[3]. a-NETA (50-150 nM; 24 hours) decreases all cell lines viability in a dose-dependent manner [3]. a-NETA (2.5-10.0 μg/mL; 24 hours) leads to epithelial ovarian cancer (EOC) cell death associated with membrane blistering and cytoplasm leakage[3].

体内活性: a-NETA (s.c. injection; 3 mg/kg or 10 mg/kg; daily; for 30 days) significantly delays the onset of EAE with 3 mg/kg, and completely suppresses clinical signs for an average of nine days with 10 mg/kg beyond the first appearance of disease in control female C57BL/6 mice[2]. a-NETA (injected intraperitoneally; 0.125 mg/kg; once every other day for 20 days) significantly decreases tumor volume and tumor weight[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 31.25 mg/mL (84.63 mM)


关键字: histamine | Cholinesterase (ChE) | Apoptosis | ChE | b-NETA | KCl | β NETA | a-NETA | ChA | choline acetyltransferase | βNETA | β-NETA | alpha-NETA | Inhibitor | cholinesterase | beta-NETA | inhibit

相关产品: TA-03 | Aldicarb sulfone | SEW06622 | Coumaran | Cotoin | Swertianolin | Nizatidine | Acotiamide monohydrochloride trihydrate | Azamethiphos | Demecarium bromide

相关库: Anti-Neurodegenerative Disease Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途