化合物AZD9056 hydrochloride T14385

Product Introduction
Bioactivity


英文名: AZD9056 hydrochloride

描述: AZD9056 hydrochloride 是一种 P2X7 抑制剂，在炎症和引起疼痛的疾病中起重要作用。

体外活性: The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line, indicating a high selectivity of the antagonist for the P2X7 receptor.The P2X7-receptor antagonist AZD9056 has a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1].

体内活性: Treatment with AZD9056 shows pain-relieving and anti-inflammatory effects. The upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues is reversed by AZD9056[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 48 mg/mL (105.39 mM)


关键字: AZD 9056 Hydrochloride | AZD9056 hydrochloride | AZD 9056 | AZD-9056 | AZD9056 Hydrochloride | P2X Receptor | P2XRs | Inhibitor | AZD-9056 Hydrochloride | AZD-9056 hydrochloride | AZD9056 | inhibit

相关产品: BX430 | Sivopixant | AZ10606120 dihydrochloride | CE-224535 | GW791343 dihydrochloride | KN-62 | PSB-12062 | AZ 11645373 | A-804598 | Oxidized ATP trisodium salt

相关库: Ion Channel Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途